Calcium channel blockers also called calcium antagonists relax and widen blood vessels by affecting the muscle cells in the arterial walls some calcium channel blockers have the added benefit of slowing your heart rate which can further reduce blood pressure relieve chest pain angina and control an irregular heartbeat. Clinical indications for calcium channel blockers somani p mayhew he ca2 channel blocking agents have proven to be one of the most exciting groups of drugs for management of many cardiovascular diseases and as potentially first line agents for treatment of angina pectoris and hypertension. The strong clinical bias of the present book should be complimented by further reading of books slanted towards fundamentals one of the most important and recent of these is that by dr winifred nayler calcium antagonists academic press 1988 that book should be basic for essential background knowledge in the area of calcium antagonists. A survey of the pharmacokinetic properties of the three prototypical calcium antagonist agents shows that they have in common a very high rate of hepatic first pass metabolism with in the case of . Calcium channel blocking agents restrict the amount of calcium entering cardiac and smooth muscle cells by blocking voltage gated calcium channels this causes blood vessels to relax and widen vasodilate improves oxygen supply to the heart and lowers blood pressure some calcium channel blockers also slow the heart rate
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