Thrombolytic medicines are approved for the emergency treatment of stroke and heart attackthe most commonly used drug for thrombolytic therapy is tissue plasminogen activator tpa but other drugs can do the same thing. Clinical practice guidelines published by both the american heart association and american stroke association aha asa in 2007 and the american college of chest physicians in 2008 recommend the use of the thrombolytic agent recombinant tissue plasminogen activator rtpa for the treatment of acute ischemic stroke ais in eligible patients 1 2. Tissue plasminogen activator abbreviated tpa or plat is a protein involved in the breakdown of blood clots it is a serine protease ec 342168 found on endothelial cells the cells that line the blood vessels . Tissue plasminogen activator tpa is a naturally occurring fibrinolytic agent found in vascular endothelial cells and is involved in the balance between thrombolysis and thrombogenesis. Special article from the new england journal of medicine cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction
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